Aminobenzoic acids and derivatives
eMolecules 138-14-7 | Deferoxamine mesylate | Apollo Scientific US - Building Blocks | MFCD00058605 | 656.790 | C26H52N6O11S | 0.000 | CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN | 10g | 398007525
Deferoxamine mesylate | Apollo Scientific US - Building Blocks | 138-14-7 | MFCD00058605 | 656.790 | C26H52N6O11S | 0.000 | CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN | 10g | 398007525
Medchemexpress LLC Gabexate (mesylate) | 56974-61-9 | 98.64% | 100 MG
Gabexate mesylate (FOY) is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. It inhibits human thrombin, urokinase, plasmin, and Factor Xa, and binds to human and bovine tryptase. It is used for pancreatitis and disseminated intravascular coagulation, and decreases proliferation rate in HepG2 cells in vitro.
- Anticoagulant effect by inhibiting the clotting activity of thrombin.
- Anti-inflammatory effect through the inhibition of NF-κB, proinflammatory cytokines, and nitric oxide.
- Therapeutic applications for pancreatitis and disseminated intravascular coagulation.
- Decreases the proliferation rate of HepG2 cells in a dose-dependent manner.
- Attenuates the development of mechanical allodynia induced by spinal nerve ligation (SNL) and inhibits the expression of pro-inflammatory cytokines after SNL in a rat model.
Medchemexpress LLC PBT434 mesylate | 2387898-69-1 | 99.9% | 50 MG
PBT434 mesylate is the methanesulfonate salt of a small-molecule inhibitor of α-synuclein aggregation that demonstrates oral activity and crosses the blood-brain barrier, supplied for preclinical research. It also exhibits iron-modulating properties and is provided as a high-purity solid with defined storage conditions.
- High purity: 99.9%.
- Molecular weight 398.26 g·mol⁻1.
- Chemical formula C13H17Cl2N3O5S.
- Available in small pack sizes including 50 MG.
- Store sealed at 4°C; in solvent keep at -80°C up to 6 months, or -20°C up to 1 month.
- Intended for preclinical studies of protein aggregation and iron modulation; follow appropriate safety guidance.
Medchemexpress LLC Reboxetine mesylate | 98769-84-7 | 99.7% | C20H27NO6S | 50 MG
Reboxetine mesylate is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) primarily used for depression research. It effectively inhibits norepinephrine uptake with a Ki of 8 nM.
- Weak affinity for muscarinic, histaminergic H1, adrenergic α1, and dopaminergic D2 receptors.
- Prevents dexamethasone-induced decreases in cell viability and proliferation rate in SH-SY5Y cells (0.1 μM, 1 μM, 5 μM for 24 hours).
- Significantly decreases immobility time in mice depression models (30 mg/kg; i.p.).
Medchemexpress LLC Masitinib mesylate | 1048007-93-7 | MFCD12546334 | 100.0% | 594.75 g/mol | C29H34N6O4S2 | 5 MG
Masitinib mesylate is the mesylate salt form of masitinib, a small-molecule tyrosine kinase inhibitor. It is supplied as a high-purity analytical and research compound for in vitro and analytical applications and selectively inhibits c-Kit, PDGFR, and Src family kinases.
- Purity 99.98%.
- Molecular weight 594.75 g/mol.
- Molecular formula C29H34N6O4S2.
- Solubility in DMSO ≥ 30 mg/mL.
- Intended for research and analytical use.
- Available in a 5 mg pack size.
Medchemexpress LLC Enasidenib mesylate | 1650550-25-6 | 99.7% | 569.48 | 1 ML
Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes. It is for research use only.
- Reverses effects of mutant IDH2 on DNA methylation.
- Induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells.
- Improves survival in IDH2-mutant acute myeloid leukemia models.
- Remodels the epigenetic state of IDH2-mutant cells.
- Reduces 2-HG in vivo and restores differentiation.
Medchemexpress LLC Pefloxacin mesylate | 70458-95-6 | 99.7% | 1 G
Pefloxacin mesylate is a broad-spectrum antibiotic that blocks DNA replication by inhibiting DNA gyrase and DNA relaxation catalyzed by topoisomerase I. It exhibits antibacterial activity against various bacteria such as *Escherichia coli*, *Pseudomonas aeruginosa*, and *Bacteroides fragilis*. It has also shown activity against *Plasmodium yoelii* infection and can increase UVA-induced edema and immunosuppression, making it suitable for infection studies.
- Inhibits DNA replication by blocking DNA gyrase
- Inhibits DNA relaxation catalyzed by topoisomerase I (IC50 of 45 μg/mL)
- Exhibits broad-spectrum antibacterial activity
- Active against *Escherichia coli*, *Pseudomonas aeruginosa*, and *Bacteroides fragilis*
- Demonstrates activity against *Plasmodium yoelii* infection
- Increases UVA-induced edema and immunosuppression
- Suitable for infection studies
Medchemexpress LLC AZ7550 mesylate (AZ7550 trimesylate salt) | 2319837-99-3 | 98.7% | 773.90 g·mol⁻¹ | C30H43N7O11S3 | 10 MG
AZ7550 mesylate is the mesylate (trimesylate) salt of AZ7550, an active metabolite of AZD9291 that inhibits IGF1R (IC50 = 1.6 μM). It is provided as an analytical standard for biochemical and cellular research and is offered in small milligram packages and solution formats for assay use.
- Mesylate (trimesylate) salt form for improved handling and solubility.
- Reported IGF1R inhibitory activity with IC50 = 1.6 μM.
- High purity (~98.7%), suitable as an analytical standard.
- Molecular weight 773.90 g·mol⁻¹ and formula C30H43N7O11S3.
- Available in small quantities (5-100 mg) and as DMSO solutions for assay readiness.
Medchemexpress LLC Sns-314 mesylate | 1146618-41-8 | ≥98.0% | 25 MG
SNS-314 mesylate is the mesylate salt of SNS-314, a potent pan-Aurora kinase inhibitor active against Aurora A, B, and C used in preclinical research to investigate mitotic regulation and antineoplastic mechanisms.
- Potent inhibition of Aurora A, B, and C (IC50 ≈ 9, 31, and 6 nM)
- High purity: ≥98%
- Powder form, soluble in DMSO for screening and formulation
- Typical storage: -20 °C to preserve stability
- Provided as mesylate salt; formula C18H15ClN6OS2 • CH3SO3H, formula weight 527.0
Medchemexpress LLC Nafamostat mesylate | 82956-11-4 | >99.8% | 1 ML
Nafamostat mesylate (FUT-175) is an anticoagulant and a synthetic serine protease inhibitor. It demonstrates anticancer and antivirus effects. It induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1) and can be utilized in the development of treatments for the pathological thickening of the arterial wall.
- Anticoagulant
- Synthetic serine protease inhibitor
- Demonstrates anticancer effects
- Demonstrates antivirus effects
- Induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1)
- Can be utilized in the development of treatments for pathological thickening of the arterial wall
Medchemexpress LLC Fgti-2734 (mesylate) | 2702297-24-1 | 99.7% | 10 MM 1 ML
FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor. It can prevent membrane localization of KRAS, which helps to solve KRAS resistance and thwart mutant KRAS patient-derived pancreatic tumors.
- Functions as a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor.
- Exhibits IC50s of 250 nM for FT and 520 nM for GGT.
- Prevents membrane localization of KRAS.
- Addresses KRAS resistance.
- Thwarts mutant KRAS patient-derived pancreatic tumors.
- Induces apoptosis in mutant KRAS-dependent human cancer cells (in vitro).
- Inhibits protein prenylation of HDJ2, RAP1A, KRAS, and NRAS (in vitro).
- Inhibits tumor growth in mutant KRAS-dependent tumors (in vivo).
Medchemexpress LLC Nafamostat formate salt-13C6 | 98.1% | 1 MG
Nafamostat formate salt-13C6 is a 13C labeled Nafamostat, a synthetic serine protease inhibitor and anticoagulant. It suppresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis, and also blocks activation of SARS-CoV-2. This compound is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Features a 13C labeled structure.
- Acts as a synthetic serine protease inhibitor.
- Functions as an anticoagulant.
- Suppresses T cell auto-reactivity.
- Blocks activation of SARS-CoV-2.
Apexbio Technology LLC Trovafloxacin mesylate 147059-75-4 50mg
Trovafloxacin mesylate (CAS 147059-75-4) is a small-molecule inhibitor targeting bacterial DNA topoisomerase IV and DNA gyrase It is designed to interfere with DNA replication and transcription thereby inhibiting bacterial DNA synthesis Trovafloxacin mesylate exerts its biological activity primarily through stabilization of the quinolone-DNA-enzyme complex leading to inhibition of DNA synthesis in bacterial cells In enzymatic assays Trovafloxacin mesylate demonstrates inhibitory activity with IC50 values typically within the nanomolar to low micromolar range depending on bacterial targets and assay conditions Based on these pharmacological properties Trovafloxacin mesylate holds research potential in antibacterial mechanism analysis resistance pathway examination and pharmacological profiling against both Gram-positive and Gram-negative bacteria
Apexbio Technology LLC Delavirdine mesylate 147221-93-0 100mg
Delavirdine mesylate (CAS 147221-93-0) is a small-molecule inhibitor targeting HIV-1 reverse transcriptase It is designed to selectively inhibit the enzymatic activity of HIV-1 reverse transcriptase thereby disrupting viral DNA synthesis and impeding HIV replication Delavirdine mesylate exerts its biological activity primarily through direct binding to an allosteric site on HIV-1 reverse transcriptase In biochemical studies delavirdine mesylate demonstrates inhibitory activity against HIV-1 reverse transcriptase with an IC50 value of 0 26 M Based on these pharmacological properties delavirdine mesylate holds research potential in antiviral assays HIV resistance studies and mechanistic investigations into NNRTI-related enzyme inhibition